Identification of minimal sequence for HIV-1 fusion inhibitors.

نویسندگان

  • Hiroki Nishikawa
  • Shinya Oishi
  • Mizuno Fujita
  • Kentaro Watanabe
  • Rei Tokiwa
  • Hiroaki Ohno
  • Eiichi Kodama
  • Kazuki Izumi
  • Keiko Kajiwara
  • Takeshi Naitoh
  • Masao Matsuoka
  • Akira Otaka
  • Nobutaka Fujii
چکیده

Emergence of multi-drug resistant HIV-1 is a serious problem for AIDS treatment. Recently, the virus-cell membrane fusion process has been identified as a promising target for the development of novel drugs against these resistant variants. In this study, we identified a 29-residue peptide fusion inhibitor, SC29EK, which shows activity comparable to the previously reported inhibitor SC35EK. Some residues in SC29EK not required for interaction with virus gp41 heptad repeat 1 (HR1) were replaced with a non-proteinogenic amino acid, 2-aminoisobutyric acid (Aib), to stabilize the alpha-helix structure and to provide resistance to peptidases.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry

دوره 16 20  شماره 

صفحات  -

تاریخ انتشار 2008